bempedoic acid canada

For two statins, simvastatin and pravastatin, your doctor may change the dose if you also take NEXLETOL. [1], Bempedoic acid is a prodrug. The medication you requested Nexletol is not available. [2], In February 2020, bempedoic acid was approved for use in the United States. [2], Bempedoic acid was approved for use in the United States in February 2020, and for use in the European Union in April 2020. Bempedoic acid is an alpha,omega-dicarboxylic acid that is pentadecanedioic acid which is substituted by methyl groups groups at positions 2 and 14, and by a hydroxy group at position 8. Create. PRESCRIPTION DRUGS | PHARMACY MANAGER: Mohammed Hassan THIS PHARMACY IS DULY LICENSED IN THE PROVINCE OF BRITISH COLUMBIA, CANADA BY THE COLLEGE OF PHARMACISTS OF BC. [3][10][11][12] The U.S. Food and Drug Administration (FDA) granted the approval of Nexletol to Esperion Therapeutics. [5] As of March 2019[update], its effects on cardiovascular morbidity and mortality have not been determined; but studies are under way. If you have any question, please call our customer Nexletol (Bempedoic acid) is a prescription medicine used, along with diet and other lipid-lowering medicines, in the treatment of adults with heterozygous familial hypercholesterolemia (HeFH). Nexletol (Bempedoic Acid) is used along with a proper diet and other lipid-lowering medications to treat high cholesterol. [6], In January 2020, the Committee for Medicinal Products for Human Use (CHMP) in the European Union recommended granting of a marketing authorization for bempedoic acid as both a standalone drug (Nilemdo)[8] and as a combination drug with ezetimibe (Nustendi). [9] Bempedoic acid was approved for use in the European Union in April 2020. For lowering cholesterol, NEXLETOL is often taken with other medicines, including a group of medicines called statins. Bempedoic acid blocks an enzyme in the liver called adenosine triphosphate citrate lyase, which is involved in making cholesterol. NEXLETOL is a tablet that you take by mouth. [3][2], In the US, bempedoic acid is indicated for the treatment of hypercholesterolemia in combination with diet and the highest tolerated statin therapy in adults with heterozygous familial hypercholesterolemia, or with established atherosclerotic cardiovascular disease, who need additional lowering of LDL cholesterol. Bempedoic acid was approved for use in the United States in February 2020, and for use in the European Union in April 2020. PRESCRIPTIONS DISPENSED FROM CANADA ARE DISPENSED BY: CANDRUG PHARMACY, ID#18985 604-543-8711. [13] In both trials, subjects were randomly assigned to receive bempedoic acid or placebo tablets every day for 52-weeks. Bempedoic acid is used along with a proper diet and other medications to help lower "bad" cholesterol (such as LDL) in the blood. [5][6], The substance also activates AMP-activated protein kinase, but this effect is likely not relevant in humans. Copyright © 2003 - 2020 Canadian Pharmacy King. Before taking NEXLETOL, tell your doctor … It contains 180 mg of bempedoic acid. This medication works in the liver by blocking an enzyme needed to make LDL. [1], In the EU, bempedoic acid is indicated in adults with primary hypercholesterolaemia (heterozygous familial and non familial) or mixed dyslipidaemia, as an adjunct to diet in combination with a statin or statin with other lipid-lowering therapies in patients unable to reach LDL C goals with the maximum tolerated dose of a statin; or alone or in combination with other lipid-lowering therapies in patients who are statin intolerant, or for whom a statin is contraindicated. Please search with another name. CustomerService@canadianpharmacyking.com. [13] The trials were conducted in United States, Canada, and Europe. POLICIES. Gout incidence was 1.6/100 vs 0.5/100 PY in the bempedoic acid vs placebo groups. [4], Following oral intake, bempedoic acid reaches highest blood plasma concentrations after 3.5 hours. Can I take NEXLETOL with other medicines? service toll free 1.877.745.9217, or send an email to View Manufacturers, Suppliers & Exporters of Bempedoic Acid API listed on PharmaCompass.com [1], Bempedoic acid has a biological half-life of 21±11 hours. HeFH is an inherited condition that causes high levels of “bad” cholesterol called low density lipoprotein (LDL). New-onset diabetes/hyperglycemia occurred less frequently with bempedoic acid vs … It is a drug used for the treatment of high LDL cholesterol, which is … [13] The trial designs were similar. [1] Food does not affect its absorption. [1] Over 95% of the substance are excreted in form of metabolites; about 70% with the urine and 30% with the feces. [1], In a study, it reduced LDL cholesterol by about 20 mg/dl compared to placebo and had no more side effects than placebo, although a higher percentage of drug receiving subjects dropped out of the study because of side effects (11% vs. 7% under placebo). ALL PRICES ARE IN US DOLLARS. By inhibiting ACL, bempedoic acid suppresses cholesterol synthesis, 8 thereby triggering the upregulation of LDL receptor expression in the liver, resulting in increased clearance of LDL particles and lowering of LDL-cholesterol in the blood. [13], The trials measured percent change in LDL-C blood levels from baseline to week 12 and compared bempedoic acid to placebo. [1] About a fifth of the substance is reversibly converted by an aldo-keto reductase enzyme to a metabolite (called ESP15228) that is also pharmacologically active in form of its coenzyme A–thioester. 2006-10-25. Despite this, the drug increases blood levels of statins. [2], Common adverse effects in clinical trials were muscle spasms (3.6% of treated patients, as compared to 2.3% under placebo), pain in the back (3.3% versus 2.2%) or in a limb (3.0% versus 1.7%), gout (1.5% versus 0.4%), and gastrointestinal problems such as diarrhea. Bempedoic acid is a first-in-class adenosine triphosphate-citrate lyase (ACL) inhibitor. Lowering "bad" cholesterol may help to decrease the risk of heart … The effect is most pronounced with simvastatin and pravastatin, whose AUC is increased about twofold. [1] Of ESP15228, 99.2% are bound to plasma proteins. Bempedoic acid (ETC-1002), a small molecule drug, promotes low density lipoprotein (LDL) receptor mediated clearance of LDL-cholesterol (LDL-C) by inhibition of adenosine triphosphate citrate lyase (ACL), a mechanism complementary to those of existing lipid-modifying therapies. [13], There were two clinical trials that evaluated the benefits and side effects of bempedoic acid. Bempedoic acid, sold under the brand name Nexletol among others, is a medication for the treatment of hypercholesterolemia. It works by reducing the amount of cholesterol made by the liver. Bempedoic acid, sold under the brand name Nexletol among others, is a medication for the treatment of hypercholesterolemia (high blood cholesterol levels). A less common but more serious adverse effect was tendon rupture in the rotator cuff of the shoulder, the biceps tendon or the Achilles tendon (0.5% versus 0.0%). [1], The FDA approved bempedoic acid based on evidence from two clinical trials (Trial 1/ NCT02666664 and Trial 2/NCT02991118) of 3009 subjects with high LDL cholesterol and known atherosclerotic cardiovascular disease or HeFH. [1][2], Bempedoic acid blocks an enzyme in the liver called adenosine triphosphate citrate lyase, which is involved in making cholesterol. All rights reserved. These laboratory abnormalities were apparent by week 4, stable over time, and reversible after treatment cessation. CANADIAN PHARMACY KING | [1], Bempedoic acid does not interact with the cytochrome P450 enzyme system in the liver and only weakly inhibits the transporter proteins SLCO1B1, SLCO1B3 and SLC22A7 (the latter possibly being responsible for the increase of uric acid in the blood, and therefore the adverse effect gout). [13] All enrolled subjects were on a low cholesterol diet and taking the highest dose of a statin (drug commonly used to lower cholesterol), for high cholesterol. [1] Both bempedoic acid and the metabolite are inactivated by glucuronidation of their carboxylic acid groups. It is activated to the thioester with coenzyme A by the enzyme SLC27A2 in the liver. [13] Neither the subjects nor the health care providers knew which treatment was being given. [1] When in the bloodstream, 99.3% of the substance are bound to plasma proteins. Bempedoic acid was associated with mild increases in blood urea nitrogen, creatinine, and uric acid and decreases in hemoglobin.